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AssigneesThe Board of Trustees of the Leland Stanford Junior University, CZ Biohub SF, LLC
InventorsAbigail E. Powell, Payton Anders-Benner Weidenbacher, Natalia Friedland, Mrinmoy Sanyal, Peter S. Kim
Estimating the term…
Provided are fusion proteins including an amino acid sequence of an ectodomain of Spike protein of a coronavirus, such as SARS-CoV-2, joined to an amino acid sequence of a ferritin subunit polypeptide. Nanoparticles including such fusion proteins, with surface-exposed trimers of the ectodomain of the Spike protein of the coronavirus, are also provided. Also provided are nucleic acids and vectors encoding the fusion proteins, cells containing such nucleic acid and vectors, immunogenic compositions including the fusion proteins, the nanoparticles, or the vectors, as well as corresponding methods and kits.
A fusion protein of an artificially modified amino acid sequence of a Spike protein of a coronavirus and an amino acid sequence of a ferritin subunit polypeptide, wherein the artificially modified amino acid sequence of the Spike protein is a sequence with at least 90% sequence identity to SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:14, or SEQ ID NO:15.
Dependencies are inferred from the claim text.