Method and apparatus for cancer treatment
AssigneeMinnesota Medical Physics LLC
InventorsVictor I. Chornenky, Ali Jaafar
Life of this patent
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Abstract
Methods and apparatus for treatment of cancer are provided. The method can include systemic delivery of A3 selective adenosine receptor (A3AR) agonists CI-IB-MECA, cordycepin or similar drugs and providing simultaneous pulsed Electric Field (EF) stimulation to the treatment area. EF stimulation can be delivered in three orthogonal directions, which significantly increases expression of A3ARs on the cellular membranes and allows achieving a downstream apoptotic signal that is 4-6 fold stronger than the signal achieved with the agonist drugs alone.
Claims13
A method of treating a cancerous tumor in a patient, comprising:
- providing pulsed electric field stimulation to the tumor to increase the expression of A3ARs on a surface of cancer cells of the tumor;
- and
- delivering a dose of A3AR agonist to the patient to induce apoptosis of the cancer cells of the tumor.
A method of opening a patient's blood-brain barrier to their brain, comprising:
- delivering a systemic dose of A2aAR agonist to the patient;
- and
- providing pulsed electric field stimulation (EFS) to the brain of the patient.
A method of inducing apoptosis of cancer cells of a tumor in the brain of a patient, comprising:
- delivering a systemic dose of an A2aAR agonist to the patient;
- providing electric field stimulation to the brain to simultaneously increase the expression of A2aARs on the cells responsible for blood-brain barrier permeation and the expression of A3ARs on the surface of cancer cells of the tumor;
- and
- delivering a systemic dose of A3AR agonist to the patient that reaches the tumor in the brain via the permeated blood-brain barrier.
Dependencies are inferred from the claim text.