Therapeutic carbon monoxide formulations
AssigneesThe Brigham and Women's Hospital, Inc., Massachusettis Institute of Technology, Beth Israel Deaconess Medical Center, Inc.
InventorsCarlo Giovanni Traverso, James D. Byme, Hannah Boyce, Leo E. Otterbein, David J. Gallo
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Abstract
A pharmaceutical composition is described that includes a pharmaceutical carrier comprising gas pockets containing carbon monoxide gas, wherein the pharmaceutical carrier is a foam, a solid, or a hydrogel. Methods of using the pharmaceutical composition to treat an inflammatory disease or condition, and methods of making the pharmaceutical composition, are also described.
Claims26
A pharmaceutical composition, comprising a pharmaceutical carrier comprising gas pockets containing carbon monoxide gas, wherein the pharmaceutical carrier is a foam, a solid, or a hydrogel.
A method of treating an inflammatory disease or condition in a subject in need thereof, comprising administering a therapeutically effective amount of carbon monoxide gas to the subject, wherein the carbon monoxide gas is administered using a pharmaceutical composition, comprising a pharmaceutical carrier comprising gas pockets containing carbon monoxide gas, wherein the pharmaceutical carrier is a foam, a solid, or a hydrogel.
A method of making a foam or hydrogel pharmaceutical composition comprising a pharmaceutical carrier comprising gas pockets containing carbon monoxide gas, comprising the steps of:
- a) dissolving xanthan gum, methylcellulose, maltodextrin, and optionally alginate into an aqueous solution to form a carrier solution;
- b) heating the carrier solution to boiling;
- c) cooling the carrier solution to about room temperature;
- and
- d) injecting carbon monoxide gas into the carrier solution to form a foam.
Dependencies are inferred from the claim text.