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US 2023/0398073 A1Published application
Pharmaceutical compositions for the treatment of ophthalmic conditions
AssigneeRhodes Technologies
InventorsPing CHANG, Zhenze Hu, Yuanyuan TAO
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Abstract
The invention provides emulsion compositions comprising at least one cannabinoid compound, and methods for making the same. The emulsion compositions are stable, well tolerated and are capable of delivering therapeutically effective amounts of cannabiniods to target sites, including sites on the surface of and/or within an eye. Also provided are methods of using the compositions to provide ocular neuroprotection and/or to treat ophthalmic conditions such as glaucoma.
Claims119
An emulsion composition comprising:
- tetrahydrocannabinol (THC), or a derivative thereof;
- an oil;
- a surfactant;
- and
- water,
- wherein the emulsion comprises an oil phase component comprising a plurality of oil droplets, dispersed with an aqueous phase component, the emulsion remains stable after being stored at a condition selected from the group consisting of:
- at least two years at about −18° C.;
- at least three months at about 4° C.;
- and at least one month at about 23° C., such that there is an absence of visible phase separation between the oil phase component and the aqueous phase component after such storage condition.
6 more elements
An emulsion composition comprising:
- a tetrahydrocannabinol (THC), or a derivative thereof;
- an oil;
- a surfactant;
- and
- water,
- wherein the emulsion comprises an oil phase component comprising a plurality of oil droplets dispersed with an aqueous phase component, wherein the osmolarity of the emulsion is substantially similar to human tear fluid osmolarity.
3 more elements
An emulsion composition comprising:
- (−)-trans-Δ9-tetrahydrocannabinol;
- an oil selected from sesame oil, castor oil, or a combination thereof;
- a surfactant selected from the group consisting of Tween® 80 (polyoxyethylene (20) sorbitan monooleate);
- Tween® 20 (polyoxyethylene (20) sorbitan monolaurate);
- Tyloxapol (4-(1,1,3,3-Tetramethylbutyl)phenol polymer with formaldehyde and oxirane);
- Span 80 (Sorbitane monooleate);
- Kollipher® HS 15 (polyoxyethylated 12-hydroxystearic acid);
- polyoxyl 35 castor oil;
- polyoxyl 40 hydrogenated castor oil;
- and polyoxyl 40 sterate, or a combination thereof;
- and
- water,
- wherein the ratio (w/w) of oil to water in the composition is in the range of about 1:20 to about 1:100, the emulsion comprises an oil phase component comprising a plurality of oil droplets dispersed with an aqueous phase component, wherein at least about 90% of the oil droplets in the emulsion are less than about 200 nm in diameter.
10 more elements
Dependencies are inferred from the claim text.