US 2023/0398049 A1 · TETRAPEPTIDES, COMPOSITIONS COMPRISING THEM, AND THEIR COSMETIC USE

Abstract

They have the general Formula X-(Xaa)nLE(Xaa)m-Z wherein Xaa is selected from L, K, E and D, either n=2 and m=0, or n=1 and m=1, at the N-terminal end X being selected from H, —CO—R1, —SO2-R1 or a biotinoyl group, at the C-terminal end Z being selected from OH, OR1, NH2, NHR1 or NR1R2, and R1 and R2 being selected from an alkyle, aryle, aralkyle, alkylaryl, alkoxy, saccharide and aryloxy, said group having from 1 to 24 carbon atoms. Preferred peptide sequences are X-LKLE-Z and X-ELED-Z. These tetrapeptides stimulate the synthesis of molecules constituting the ECM, in particular collagen 1 and 4, hyaluronic acid and fibronectin, and can be used for a cosmetic treatment, in particular anti-aging, anti-wrinkle and fine lines, to improve the skin mechanical properties, to increase skin density and volume, hydration, and/or to fight against stretch marks, and skin sagging.

Claims17

Dependent claims

A tetrapeptide of Formula 1:

X-(Xaa)nLE(Xaa)m-Z (SEQ ID NOS:
6 to 39)
wherein:
Xaa is an amino acid chosen from L, K, E and D, the Xaa being chosen independently of each other;
either n=2 and m=0, or n=1 and m=1;
at the N-terminal X chosen from H, —CO—R1, —SO2—R1 or a biotinoyl group;
at the C-terminal Z end chosen from OH, OR1, NH2, NHR1 or NR1R2;
and
R1 and R2 being, independently of each other, chosen from an alkyl, aryl, aralkyl, alkylaryl, alkoxy, saccharide and aryloxy group, which may be linear, branched, cyclic, polycyclic, unsaturated, hydroxylated, carbonylated, phosphorylated and/or sulfured, the group having from 1 to 24 carbon atoms and optionally having in its backbone one or more heteroatoms O, S and/or N.

6 more elements

Dependencies are inferred from the claim text.

Tetrapeptides, compositions comprising them, and their cosmetic use

Life of this patent

Tetrapeptides, compositions comprising them, and their cosmetic use

Life of this patent

Abstract

Claims17