Systems For Producing Cellular Immunotherapeutics And Methods Of Use Thereof
AssigneeNortheastern University
InventorShashi K. Murthy
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Abstract
Devices, systems, and methods can be used for the automated production of dendritic cells (DC) from dendritic cell progenitors, such as monocytes obtained from peripheral blood, and the automated generation of immunotherapeutic products from those dendritic cells, all within a closed system. The invention makes it possible to obtain sufficient quantities of a subject's own DC for use in preparing and characterizing vaccines, for activating and characterizing the activation state of the subject's immune response, and to aid in preventing and/or treating cancer or infectious disease.
Claims20
A system for producing an immunotherapeutic product, the system comprising:
- a first module configured for processing cellular material associated with a disease of a patient;
- a second module configured for generating immune cells;
- and
- a third module in fluidic communication with the first and second modules such that the third module receives a flow of processed cellular material from the first module and a flow of immune cells from the second module, wherein the third module is configured to co-culture the processed cellular material and the immune cells to produce an immunotherapeutic product.
Dependencies are inferred from the claim text.