Use of reelin for treating cardiac diseases
OwnerGuillermo Oliver, Xiaolei Liuinventors
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Abstract
Disclosed herein are compositions and methods useful for treating diseases, conditions and injuries of the heart, and/or improving cardiac function in a subject in need thereof. In some embodiments, the methods comprise administering a therapeutically effective amount of a reelin polypeptide, a functional fragment or variant thereof, or a nucleic acid that expresses a reelin polypeptide or a functional fragment or variant thereof, to the subject.
Claims20
A method for treating a disease or condition of the heart in a subject in need thereof, the method comprising:
- administering to the subject a composition comprising a reelin polypeptide or a variant thereof.
A method for improving cardiac function in a subject in need thereof, the method comprising:
- administering an effective amount of reelin polypeptide, or a variant thereof.
A method to stimulate the formation of new lymphatics in cardiac tissue in a subject in need thereof, the method comprising administering an effective amount of reelin polypeptide, or a variant thereof.
A composition comprising:
- a reelin polypeptide embedded in a collagen patch.
Dependencies are inferred from the claim text.