Uses of chk2 inhibitors
AssigneeThe University of Birmingham
InventorsZubair Ahmed, Richard Ian Tuxworth
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to the treatment of neurological conditions, by inhibiting Chk2 kinase. Particular neurological conditions may be associated with neuronal damage/dysfunction or neurological degeneration, which may result from, physical trauma, chemical means, infection, inflammation, hypoxia and/or interruption in blood supply, or be due to a neurodegenerative disorder and/or autoimmune disease. The Chk2 inhibitor may be a small molecule, protein, peptide or nucleic acid. Exemplary small molecule Chk2 inhibitors include PV1019, AZD7762, CCT241533, BML-277 or prexasertib.
Claims15
A Chk2 inhibitor for use in a method of protecting against or treating neuronal damage/dysfunction or neuronal degeneration in a subject.
The Chk2 inhibitor for use according to any one of the preceding claims, wherein the neuronal damage/dysfunction or neuronal degeneration is caused by, or may result from, physical trauma, chemical means, infection, inflammation, hypoxia and/or interruption in blood supply.
The Chk2 inhibitor for use according to any one of the preceding claims, wherein the neuronal damage/dysfunction or degeneration is central nervous system or peripheral nervous system damge or degeneration.
The Chk2 kinase inhibitor for use according to 7, wherein the neuronal damage/dysfunction or degeneration in the peripheral nervous system is a peripheral neuropathy.
The Chk2 inhibitor for use according to any one of the preceding claims, wherein the Chk2 inhibitor inhibits expression or activity of Chk2.
The Chk2 inhibitor for use according to any one of the preceding claims, wherein the Chk2 inhibitor is a small molecule, protein, peptide or nucleic acid.
An intrathecal or intraparenchymal delivery system comprising a reservoir containing a pharmaceutical formulation comprising a Chk2 inhibitor, a pump and a catheter or the like to deliver the formulation to an appropriate location in the brain, spinal cord/canal or surrounding tissue.
Dependencies are inferred from the claim text.