Systems, devices, and formulations for time-phased histamine delivery

Abstract

Aspects of the disclosure provided herein relate to compositions and methods for providing a drug delivery through a transdermal patch. Some other embodiments relate to a transdermal drug delivery patch comprising a bottom layer comprising a skin side liner, a middle layer comprising a gel, a top layer comprising a release liner, wherein the adhesive or gel comprises at least one drug capable of modulating histamine in a subject. Some other embodiments provided herein relate to a transdermal drug delivery system for delivery of at least one drug into a tissue membrane of a subject. Some other embodiments relate to a transdermal drug delivery patch comprising a bottom layer comprising a skin side liner, a middle layer comprising a gel/adhesive, a top layer comprising a release liner, wherein the gel comprises at least one drug capable of modulating histamine receptors in a subject.

Dependencies are inferred from the claim text.