Gastro retentive dosage forms comprising deutetrabenazine
AssigneeAuspex Pharmaceuticals, Inc.
InventorsMayank JOSHI, Parag SHAH, Soumen PATTANAYEK, Divyang PATEL, Sandeep PANDITA
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Abstract
Provided herein are controlled release gastro retentive dosage forms containing deutetrabenazine for use in the treatment of, e.g., hyperkinetic movement disorders. When orally administered to a subject on a once-daily basis, the dosage forms provide a favorable pharmacokinetic profile.
Claims78
A controlled release gastro retentive solid oral dosage form for once daily administration of deutetrabenazine comprising:
- a. an amount of deutetrabenazine;
- b. at least two control release polymers, each independently having a viscosity of 2,000 cPs or more;
- and
- c. a pharmaceutically acceptable excipient comprising at least one disintegrant;
- wherein the total amount of control release polymers is at least 30 wt. % relative to the total weight of the dosage form.
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Dependencies are inferred from the claim text.