Pharmaceutical combinations for treating cancer
AssigneePolyphor AG
InventorsMichael BAUER, Leon HOOFTMAN, Barbara ROMAGNOLI
Life of this patent
Estimating the term…
Abstract
The present invention relates to pharmaceutical combinations comprising a compound of formula T or a pharmaceutically acceptable salt thereof and cyclo(-Tyr-His-Ala-Cys-Ser-Ala-DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-DPro-Pro-) having a disulfide bond between Cys4 and Cys11 or a pharmaceutically acceptable salt thereof and their use in a method for the prevention, delay of progression or treatment of cancer in a subject.
Claims19
A pharmaceutical combination comprising:
- (a) a compound of formula I
- which has the chemical name 2-(3-amino-2-hydroxypropyl)hexacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)11,15-18,21-24,28-triepoxy-7,9-ethano-12,15-methano-9H,15H-furo(3,2-i)furo(2′,3′-5,6)pyrano(4,3-b)(1,4)dioxacyclopentacosin-5-(4H)-one or a pharmaceutically acceptable salt thereof;
- (b) cyclo(-Tyr-His-Ala-Cys-Ser-Ala-DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-DPro-Pro-) having a disulfide bond between Cys4 and Cys11, or a pharmaceutically acceptable salt thereof;
- and optionally
- (c) one or more pharmaceutically acceptable diluents, excipients or carriers.
(canceled)
A kit of parts comprising a first container, a second container and a package insert, wherein the first container comprises at least one dose of a medicament comprising a compound of formula I or a pharmaceutically acceptable salt thereof or a compound of formula Ia, the second container comprises at least one dose of a medicament comprising cyclo(-Tyr-His-Ala-Cys-Ser-Ala-DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-DPro-Pro-) having a disulfide bond between Cys4 and Cys11, or a pharmaceutically acceptable salt thereof, and the package insert comprises instructions for treating a subject for cancer using the medicaments, wherein the cancer is selected from the group consisting of breast cancer, metastatic breast cancer, and relapsed metastatic breast cancer.
Dependencies are inferred from the claim text.