Phosphate-containing copolymers for virulence suppression

A medical composition comprising a phosphate-containing copolymer, wherein the medical composition is suitable for administration to a mammal and wherein the phosphate-containing copolymer comprises a first copolymeric unit comprising:

• (a) monomeric units of Formula (I) and
• (b) monomeric units of Formula (II) or a salt thereof and
• (c) optional monomeric units of Formula (III)
• wherein
• R1 is hydrogen, alkyl, aryl, alkaryl, or aralkyl;
• x is mole percent monomeric units of Formula (I) based on total moles of monomeric units in the first copolymeric unit;
• y is mole percent monomeric units of Formula (II) based on total moles of monomeric units in the first copolymeric unit;
• z is mole percent monomeric units of Formula (III) based on total moles of monomeric units in the first copolymeric unit;
• (x+y+2z) is at least 90 mole percent based on total moles of monomeric units in the first copolymeric unit;
• 100[(y+2z)÷(x+y+2z)] is in a range of 3.5 to 30 percent;
• and
• each asterisk (*) denotes a connection site to another monomeric unit or to a terminal group.

A method of suppressing microbial virulence, the method comprising administering and/or applying a medical composition, the medical composition comprising a phosphate-containing copolymer, the phosphate-containing copolymer comprising a first copolymeric unit comprising:

• (a) monomeric units of Formula (I) and
• (b) monomeric units of Formula (II) or a salt thereof and
• (c) optional monomeric units of Formula (III)
• wherein
• R1 is hydrogen, alkyl, aryl, alkaryl, or aralkyl;
• x is mole percent monomeric units of Formula (I) based on total moles of monomeric units in the first copolymeric unit;
• y is mole percent monomeric units of Formula (II) based on total moles of monomeric units in the first copolymeric unit;
• z is mole percent monomeric units of Formula (III) based on total moles of monomeric units in the first copolymeric unit;
• (x+y+2z) is at least 90 mole percent based on total moles of monomeric units in the first copolymeric unit;
• 100[(y+2z)÷(x+y+2z)] is in a range of 3.5 to 30 percent;
• and
• each asterisk (*) denotes a connection site to another monomeric unit or to a terminal group.