US 2023/0332174 A1 · NUCLEIC ACID CONSTRUCT, RECOMBINANT INFLUENZA VIRUS, METHOD FOR PREPARING A RECOMBINANT INFLUENZA VIRUS, COMPOSITION AND USE

Nucleic acid construct, recombinant influenza virus, method for preparing a recombinant influenza virus, composition and use

AssigneeFundaçãO Oswaldo Cruz

InventorsAlexandre de Magalhães Vieira MACHADO, Sarah Giarola da Silva MESSIAS, Ana Paula de Faria GONÇALVES, Lídia Paula FAUSTINO, Igor A. PEREIRA, Ianca Évelyn Silva DE PAULA, Márcio Sobreira Silva ARAÚJO, Luciana Pádua TAVARES, Pedro Augusto ALVES, Marcelo Pascoal XAVIER, Kimberly Freitas CARDOSO, Ketyllen Reis Andrade DE CARVALHO

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Abstract

The present invention relates to a nucleic acid construct, a recombinant multiply-defective influenza virus, that promotes expression of an immunomodulatory protein in a host. This is applicable to the development of vaccines against infectious diseases, particularly those caused by influenza virus and Coronavirus.

Claims13

Dependent claims

Nucleic acid construct, characterized by comprising a truncated neuraminidase gene and a gene encoding an immunomodulatory protein.

Dependencies are inferred from the claim text.

Facts

Application

17/908,299Filed 20 May 2021

Priority

BR BR102020010208-721 May 2020

Published

19 Oct 2023

Term ends

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Classification30 codes

C12N 15/85
Vectors or expression systems specially adapted for eukaryotic hosts: for animal cells
C12N 15/86
For animal cells: viral vectors
A61K 39/092
Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus: streptococcus
A61K 39/12
Medicinal preparations containing antigens or antibodies: viral antigens