Aromatic ethylene compound and preparation method therefor, and intermediate, pharmaceutical composition, and application thereof

An aromatic vinyl compound of formula I-0, a tautomer thereof, a stereoisomer thereof, a racemate thereof, an isotopic derivative thereof, or their pharmaceutically acceptable salts;

• wherein:
• R1 is cyano, C1-C4 alkyl, C1-C4 alkyl substituted by one or more than one deuterium, halogen, C1-C4 alkyl substituted by one or more than one halogen;
• R3, R6, R12, R13 and R14 are independently H or deuterium;
• R2 is hydroxyl, halogen, C1-C4 alkyl, C1-C4 alkyl substituted by one or more than one RA-1, C1-C6 alkoxy or C1-C6 alkoxy substituted by one or more than one RA-2;
• RA-1 and RA-2 are independently deuterium, hydroxyl, halogen, cyano, C1-C4 alkoxy, C1-C4 alkoxy substituted by one or more than one deuterium,
• RA-1-1 is C1-C4 alkyl or C1-C4 alkyl substituted by one or more than one deuterium;
• RA-1-2 and RA-1-3 are independently H, deuterium, C1-C4 alkyl or C1-C4 alkyl substituted by one or more than one RA-1-1-1, and RA-1-1-1 is deuterium, hydroxyl or COORA-1-1-2;
• R4 and R5 are independently hydroxyl, halogen, C1-C4 alkyl, C1-C4 alkyl substituted by one or more than one RB-1, C1-C6 alkoxy, or C1-C6 alkoxy substituted by one or more than one RB-2;
• RB-1 and RB-2 are independently deuterium, hydroxyl, halogen, cyano, C6-C10 aryl, C6-C10 aryl substituted by one or more than one RB-1-3, 3- to 12-membered heteroaryl, 3- to 12-membered heteroaryl substituted by one or more than one RB-1-4, C1-C4 alkoxy, C1-C4 alkoxy substituted by one or more than one deuterium,
• in the heteroaryl, the heteroatom is selected from one or more of N, O and S, and the number of the heteroatom is 1 to 4;
• RB-1-3 and RB-1-4 are independently cyano, halogen, C1-C4 alkyl or C1-C4 alkoxy;
• RB-1-1 and RB-1-2 are independently H, deuterium, C1-C4 alkyl or C1-C4 alkyl substituted by one or more than one RB-1-1-1, and RB-1-1-1 is deuterium, hydroxyl or COORB-1-1-5;
• or, RB-1-1, RB-1-2 together with the nitrogen atom to which they are attached form a 5- to 7-membered carbon heterocycle or a 5- to 7-membered carbon heterocycle substituted by one or more than one RB-1-1-2;
• in the carbon heterocycle, the heteroatom is selected from one or more of N, O and S, and the number of the heteroatom is 1 to 4;
• RB-1-1-2 is deuterium, C1-C4 alkyl, C1-C4 alkyl substituted by one or more than one deuterium, COORB-1-1-6 or C1-C4 amido;
• RA-1-1-2, RB-1-1-5 and RB-1-1-6 are independently H, deuterium, C1-C4 alkyl or C1-C4 alkyl substituted by one or more than one deuterium;
• R7, R8, R9, R10 and R11 are independently H or deuterium;
• R15 and R16 are independently H, deuterium or halogen.