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US 2023/0321022 A1Published application
Reversibly protected thiolated electrophilic fatty acids as prodrugs
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsBruce A. Freeman, Francisco J. Schopfer, Steven Woodcock, Nicholas Khoo
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Abstract
Various embodiments of this invention are directed to pharmaceutical compositions and methods for treating disease. The compositions of such embodiments include thiolated nitro fatty acids. The methods of various embodiments include administering an effective amount of any of these pharmaceutical compositions to a patient in need of treatment.
Claims14
A composition comprising an effective amount of a thiolated nitro fatty acid of the formula:
- wherein R
- 1 and R2 are each —NO2;
- Y1 and Y2 are independently selected from —H, —COH, -COR, —COOH, and -COOR;
- wherein R is methyl, C2 to C6 alkyl, alkenyl, or alkynyl, x is an integer from 1 to 5, and q, m, p, and t are, independently, an integer from 1 to 10;
- and a pharmaceutically acceptable excipient.
2 more elements
A compound, or a pharmaceutically acceptable salt thereof, of formula:
- wherein R
- 1 and R2 are each —NO2;
- Y1 and Y2 are independently selected from —H, —COH, —COR, —COOH, and —COOR;
- x is an integer from 1 to 5, and q, m, p, and t are, independently, an integer from 1 to 10.
1 more element
Dependencies are inferred from the claim text.