Compositions for genome editing and methods of use thereof
AssigneeCibus Biotechnologies, Inc.
InventorF.C. Thomas ALLNUTT
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Abstract
The present disclosure concerns methods and compositions for inhibiting replication of viruses in mammalian cells. In some cases the virus can be African Swine Fever virus, or related viruses. The methods described herein can make use of programmable nucleases.
Claims60
A method for inhibiting infection of or reducing replication of a virus in an animal in need thereof, comprising introducing to a cell of said animal a nuclease comprising a gene-binding moiety, wherein said gene binding moiety is configured to bind at least one essential gene of said virus, or any combination thereof, wherein said virus belongs to the family Asfarviridae.
A vector comprising a sequence encoding at least one programmable nuclease configured to bind at least one essential viral gene of a virus from the family Asfarviridae.
Dependencies are inferred from the claim text.