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AssigneeNetris Pharma
InventorsROMAIN BARNAULT, CLAIRE VERZEROLI, CAROLE FOURNIER, PATRICK MEHLEN, BENJAMIN GIBERT, FABIEN ZOULIM, ROMAIN PARENT
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The netrin-1 protein displays anti-inflammatory activity in the liver and is an unexpected proinflammatory factor in CLD. The present invention provides for blocking or capturing netrin-1 in the liver for treating liver inflammation, and thus methods for treating liver inflammation. To perform this, the invention makes use of a polyclonal or monoclonal antibody specifically binding to netrin-1, including a series of humanized monoclonal antibodies.
A method for treating liver inflammation in a patient in need thereof, comprising administering said patient with an efficient amount of an anti-netrin-1 monoclonal antibody or an anti-netrin-1-binding fragment thereof.
A method for treating liver inflammation in a patient having liver inflammation wherein netrin-1 is present and has a proinflammatory action in the liver, comprising administering said patient with an efficient amount of an anti-netrin-1 monoclonal antibody or an anti-netrin-1-binding fragment thereof.
Dependencies are inferred from the claim text.