Preparation method for pyrrolopyrimidine compound
AssigneePrimeGene (Beijing) Co., Ltd.
InventorsSufeng Ma, Junru Han, Jin Wang, Wei Hu, Li Zhu
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AssigneePrimeGene (Beijing) Co., Ltd.
InventorsSufeng Ma, Junru Han, Jin Wang, Wei Hu, Li Zhu
Estimating the term…
The present application relates to a preparation method for a pyrrolopyrimidine compound, comprising: obtaining a compound 3 from a compound 2, obtaining a compound 4P2 from the compound 3, and obtaining a pyrrolopyrimidine compound of formula I by removing a protecting group from the compound 4P2. The preparation method of the present application has the advantages of simple operation, mild reaction conditions and high yield, avoids the problems of low yield and a large amount of impurities and difficult separation of same in original routes, reduces production costs, and is suitable for industrial production. Furthermore, the product yield of each step is high, and basically reaches about 80%, and even the yield of some steps can reach 90% or more.
A preparation method for a pyrrolopyrimidine compound of formula I comprising:
Intermediate compound 4P1, intermediate compound 5, or intermediate compound 6 having the formula
Dependencies are inferred from the claim text.