Cellular compositions and methods of treatment
AssigneeMesoblast International Sarl
InventorsSilviu ITESCU, Anthony SANDRASAGRA
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Abstract
The present disclosure relates to cellular compositions that are modified to introduce an oncolytic virus. Such compositions may be used to treat cancer by delivering oncolytic virus to cancer cells.
Claims49
A composition comprising STRO-1+ mesenchymal lineage precursor or stem cells, wherein said cells are modified to introduce an oncolytic virus.
A method of treating cancer in a subject, the method comprising administering a composition comprising STRO-1+ mesenchymal lineage precursor or stem cells, wherein said cells are modified to introduce an oncolytic virus.
A method of delivering an oncolytic virus into a cancer cell, the method comprising contacting a cancer cell with a STRO-1+ mesenchymal lineage precursor or stem cell that has been modified to introduce an oncolytic virus.
Dependencies are inferred from the claim text.