Radiotherapeutic bandage composition and method
AssigneeDb Thereapeutics, Inc
InventorANTHONY JOSEPH DI PASQUA
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Abstract
A bandage having an electrospun sheet having a polyacrylonitrile nanofiber embedded with a carrier nanoparticle or a carrier particle, the carrier nanoparticle or carrier particle including an activatable nuclide selected from the group consisting of yttrium-89, lanthanum-139, praseodymium-141, samarium-152, dysprosium-164, holmium-165, rhenium-185, rhenium-187, and combinations thereof. The bandage has a laminate enclosure, enclosing the electrospun sheet and the bandage has a distribution of the carrier nanoparticle or the carrier particle to emit a uniform radiation across the surface area of the bandage after neutron-activation.
Claims43
A bandage comprising:
- an electrospun sheet comprising:
- a polyacrylonitrile nanofiber embedded with a carrier nanoparticle or a carrier particle comprising:
- an activatable nuclide selected from the group consisting of yttrium-89, lanthanum-139, praseodymium-141, samarium-152, dysprosium-164, holmium-165, rhenium-185, rhenium-187, and any combination thereof;
- and
- a laminate enclosure, enclosing the electrospun sheet;
- and
- wherein the bandage has a distribution of the carrier nanoparticle or the carrier particle to emit a relatively uniform radiation across the surface area of the bandage after neutron-activation.
A bandage comprising:
- an electrospun sheet comprising:
- a polyacrylonitrile nanofiber embedded with an iron garnet nanoparticle or an iron garnet particle comprising:
- an activatable nuclide selected from the group consisting of yttrium-89, lanthanum-139, praseodymium-141, samarium-152, dysprosium-164, holmium-165, rhenium-185, rhenium-187, and combinations thereof;
- and
- a laminate enclosure, enclosing the electrospun sheet;
- and
- wherein the bandage has a distribution of the iron garnet nanoparticle or the iron garnet particle to emit a relatively uniform radiation across the surface area of the bandage after neutron-activation.
A method of forming radiotherapeutic bandages comprising:
- a. preparing carrier nanoparticles or carrier particles comprising iron garnet and an activatable nuclide selected from the group consisting of yttrium-89, lanthanum-139, praseodymium-141, samarium-152, dysprosium-164, holmium-165, rhenium-185, rhenium-187, and combinations thereof;
- b. drying and annealing the preparation;
- c. grinding the preparation;
- d. stirring and heating dimethylformamide (DMF) and polyacrylonitrile (PAN) and forming a concentration of 10% - 20% weight/volume PAN/DMF;
- e. mixing the preparation and DMF to form a suspension;
- f. sonicating the suspension in an ice bath;
- g. adding PAN/DMF to the suspension;
- h. mixing PAN/DMF and the suspension to form a mixture;
- i. adding the mixture to a carriage of an electrospinning instrument;
- j. electrospinning the mixture onto a paper substrate and forming a sheet;
- k. cutting the sheet into pieces;
- l. enclosing and sealing the pieces with a polymer laminate;
- and
- m. forming a bandage by cutting or punching the enclosed and sealed laminated pieces.
Dependencies are inferred from the claim text.