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AssigneesRoche Sequencing Solutions, Inc., Western Digital Technologies, Inc.
InventorsJuraj TOPOLANCIK, Patrick BRAGANCA, Seong-Ho SHIN, Yann ASTIER, Zsolt MAJZIK
Estimating the term…
Disclosed herein are devices, systems, and methods for monitoring single-molecule biological processes using magnetic sensors and magnetic particles (MNP). A MNP is attached to a biopolymer (e.g., a nucleic acid, protein, etc.), and motion of the MNP is detected and/or monitored using a magnetic sensor. Because the MNP is small (e.g., its size is comparable to the size of the molecule being monitored) and is tethered to a biopolymer, changes in the volume of Brownian motion of the MNP in a solution can be monitored to monitor the movement of the MNP and, by inference, the tethered biopolymer. The magnetic sensor is small (e.g., nanoscale or having a size on the order of the sizes of the MNP and the biopolymer) and can be used to detect even small changes in the position of the MNP within the sensing region of the magnetic sensor.
A method for monitoring single-molecule biological processes using a magnetic sensor having a sensing region, the method comprising:
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A system for monitoring motion of a magnetic particle coupled to a biopolymer, the system comprising:
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Dependencies are inferred from the claim text.