Nucleic acid sequencing method

A method for sequencing a nucleic acid using a contact reaction protocol, the contact reaction protocol comprising the following steps:

• a) providing a first batch of solid supports having nucleic acid molecules immobilized thereon,
• b) contacting the nucleic acid molecules immobilized on the solid supports with one or more reaction solutions to generate a signal representing one or more nucleotides that bind to the nucleic acid molecules on the solid supports, wherein each of the one or more reaction solutions is placed in a separate reaction container,
• wherein, after removing the contact between the solid supports and the reaction solutions, contacting the solid supports with one or more washing solutions to remove the reaction solutions remaining on the solid supports,
• c) detecting the signal on the solid supports, and
• f) optionally, repeating the steps b) to c),
• wherein the solid supports are unencapsulated,
• wherein the first batch of solid supports consists of one or more solid supports.