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AssigneeYale University
InventorsElias QUIJANO, Audrey TURCHICK, Peter GLAZER
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Compositions for enhanced gene editing and methods of use thereof are. The composition contains a cell-penetrating antibody and a donor oligonucleotide containing a sequence that can correct a mutation in a cell's genome. Preferably, the composition does not contain a nuclease, PNA, or nanoparticle. The compositions are used to modify the genome of a cell by contacting the cell with an effective amount of the composition. Genomic modification occurs at a higher frequency both ex vivo and in vivo, when cells are contacted with the cell-penetrating antibody and donor oligonucleotide as compared to the absence of the cell-penetrating antibody.
1-48. (canceled)
A composition comprising a non-covalent complex of
A method of modifying the genome of a cell comprising contacting the cell with an effective amount of a composition comprising a non-covalent complex of
The method of claim 81, wherein the immune deficiency syndromes is X-linked severe combined immunodeficiency or ADA deficiency.
Dependencies are inferred from the claim text.