Modified semaphorin 3a, compositions comprising the same and uses thereof
AssigneesMedical Research & Development Fund for Health Services Bnai Zion Medical Center, Technion Research & Development Foundation Limited, The Chancellor, Masters and Scholars of the University of Oxford
InventorsZahava VADASZ, Elias TOUBI, Nasren EIZA, Adi SABAG, Gera NEUFELD, Ofra KESSLER, E. Yvonne JONES
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Abstract
Provided herein are modified forms of Semaphorin 3A (Sema3A) polypeptide having one or more amino acid substitutions and/or deletions compared to a wild type Sema3A protein. Further provided are nucleic acid molecules encoding the modified Sema3A polypeptide, compositions including the same and uses thereof in treating various immune-related conditions.
Claims21
-29. (canceled)
A modified Semaphorin 3A polypeptide, said modified Semaphorin 3A polypeptide comprising an amino acid replacement at a position corresponding to position 257 in a wild type Semaphorin 3A protein having an amino acid sequence as denoted by SEQ ID NO:
- 1, wherein the replacement is with Cysteine (C);
- and a deletion of at least 100 amino acids of the C-terminal region of the corresponding wild type Semaphorin 3A.
Dependencies are inferred from the claim text.