Composition of nanoparticles as carrier for hpv-derived immunogenic fragments
AssigneesLife Science Inkubator Betriebs GmbH & Co. KG, Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
InventorsArmin KÜBELBECK, Angelika RIEMER, Sebastian KRUSE, Eva FEIDT, Agnieszka GRABOWSKA, Ellen JUNGLAS
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Abstract
The disclosure relates to a composition of nanoparticles as carrier for HPV-derived immunogenic fragments and the use of the composition for medical purposes, in particular for immunoprophylaxis or immunotherapy. The invention also relates to a vaccine containing the composition and/or nanoparticles.
Claims15
Composition comprising nanoparticles which are loaded with pharmaceutically acceptable compounds comprising one or more human papilloma virus (HPV)-derived immunogenic fragments or a variant thereof, having silicon dioxide and functional groups on the surface, wherein
- the functional groups are capable to carry and/or stabilize both negative and positive charges of the pharmaceutically acceptable compounds,
- the zeta potential of the composition has a value of at least ±15 mV,
- the nanoparticles have a particle size below 150 nm.
Dependencies are inferred from the claim text.