Serum albumin-binding polypeptides
AssigneeAvacta Life Sciences Limited
InventorsEmma Jenkins, Estelle Adam, Emma Stanley, Amrik Basran, Matthew P. Vincent, Bruno Gomes
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Abstract
Provided herein, in some embodiments, are recombinantly engineered variant of stefin polypeptides (AFFIMER® polypeptides) that binds to human serum albumin and extends the half-life of the polypeptides. Also provided herein, in some embodiments, are composition containing the polypeptides, methods of using the polypeptides, and methods of producing the polypeptides.
Claims60
A polypeptide that binds to human serum albumin (HSA) with a Kd of 1×10−6 M or less at pH 7.4, and at pH 6 binds to HSA with a Kd that is at least half a log less than the Kd for binding to HSA at pH 7.4.
A fusion protein comprising a polypeptide of any one of the preceding claims.
Dependencies are inferred from the claim text.