Novel tnf activity inhibitor compound, and pharmaceutically acceptable salt thereof

A compound of Formula III below or a pharmaceutically acceptable salt thereof:

• M1-L-M2 [Formula III]
• wherein,
• M1 and M2 may be the same or different, and are each independently a monomer radical of Formula Ia, and
• L is a linking group covalently bonding M1 and M2, and is selected from the following Formulas IVa to IVc,
• (wherein,
• X is —C(R3)2—, —N(R3)—, —O— or —S—,
• Y is —ORa, —SRa, —C(O)Ra, —C(O)ORa, —C(O)N(Ra)(Rb), —N(Ra)(Rb), —N(Ra)C(O)Rb, —N(Ra)C(O)ORb, or —N(Ra)S(O)ORb,
• A is C3-C8 cycloalkyl;
• 4- to 10-membered heterocycloalkyl containing 1 to 4 heteroatoms independently selected from the group consisting of N, O and S;
• C6-C10 aryl;
• or 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms independently selected from the group consisting of N, O and S,
• R1, R2 and R3 may be the same or different and each independently H, halo, cyano, —ORc, nitro, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, —SRc, —C(O)Rc, —C(O)ORc, —C(O)N(Rc)(Rd), —N(Rc)(Rd), —N(Rc)C(O)Rd, —N(Rc)C(O)ORd, or —N(Rc)S(O)ORd,
• Ra, Rb, Rc and Rd may be the same or different and are each independently H or C1-C6 alkyl,
• m and n are each independently an integer of 0 to 4,
• the monomer unit M1 or M2 is bonded to the linking group L through a bonding site * located in either Y or R2, and
• when Y or R2 has the above bonding site *, Y or R2 contains N, O or S atoms, and at the bonding site *, —C(O)—, —NH—, —N(C1-C6 alkyl)-, —O— or —S— radical is located),
• (wherein,
• * represents a bonding site between the monomer unit M1 or M2 and the linking group L,
• R or R′ is each independently C1-C10 alkylene, C2-C10 alkenylene, or C2-C10 alkynylene;
• Z is a single bond;
• —O—;
• —S—;
• —NH—;
• —N(C1-C6 alkyl)-;
• C3-C8 cycloalkylene;
• 4- to 10-membered heterocycloalkyl containing 1 to 4 heteroatoms independently selected from the group consisting of N, O and S;
• C6-C10 aryl;
• or 5- to 10-membered heteroaryl containing 1 to 4 heteroatoms independently selected from the group consisting of N, O and S;
• p is an integer from 1 to 5, and
• q1 and q2 are each independently an integer from 0 to 5, but q1 and q2 are not 0 at the same time).