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US 2023/0266333 A1Published application
Modifying binding molecules to minimize pre-exisiting interactions
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsGiane Oliveira SUMNER, Jihua CHEN, Michael PARTRIDGE, Albert TORRI, Manoj RAJADHYAKSHA
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Abstract
The present disclosure is directed towards modifying binding molecules in order to minimize pre-existing binding interactions, including binding molecules engineered to minimize or mitigate background reactivity in a sample matrix caused by drug non-specific binding interactions.
Claims20
A non-naturally occurring monoclonal antibody comprising a C-terminal heavy chain sequence comprising a sequence selected from the group consisting of SEQ ID NO:
- 7 and SEQ ID NO:
- 13, or an antigen-binding portion thereof.
Dependencies are inferred from the claim text.