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US 2023/0266283 A1Published application
Method for determining at least one analyte of interest
AssigneeRoche Diagnostics Operations, Inc.
InventorsDieter Heindl, Martin Rempt, Manuel Josef Seitz, Christoph Zuth
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Abstract
The present invention relates to a method for determining at least one analyte of interest. The present invention further relates to a sample element, a device, a kit and the use thereof for determining at least one analyte of interest.
Claims17
A method for determining at least one analyte of interest comprising the following steps:
- a) preparing a sample comprising a matrix and the at least one analyte of interest on a surface of a sample holder,
- wherein the matrix comprises at least one transition metal disulfide,
- wherein the transition metal disulfide is formed as particles,
- wherein step a) comprises:
- applying the sample in liquid form on the surface of a sample holder and drying the sample, wherein the applying comprises
- (i) a combined applying of the matrix and the analyte of interest, followed by drying, or
- (ii) a sequentially applying of the matrix and the analyte of interest, wherein in the case of the sequentially applying of the matrix and the analyte of interest, the drying is followed after each sequentially applying of the matrix and the analyte of interest,
- b) ionizing the at least one analyte of interest via laser irradiation having a wavelength of smaller than 400 nm, and
- c) determining the analyte of interest using mass spectrometry.
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A sample element for ionizing of at least one analyte of interest via laser irradiation having a wavelength of smaller than 400 nm,
- wherein the sample element comprises a sample holder and a sample, wherein the sample comprises a matrix and the at least one analyte of interest,
- wherein the sample holder comprises an electrically conductive surface, which faces the laser irradiation,
- wherein the matrix and the analyte of interest are arranged on the electrically conductive surface in the beam path of the laser irradiation, and
- wherein the matrix comprises or consists of a transition metal disulfide, which is formed as particles having a particle size in the range of 1 nm to 6 μm.
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Dependencies are inferred from the claim text.