Squalene hopene cyclase derivatives and use thereof for producing ambrox
AssigneeInternational Flavors & Fragrances Inc.
InventorsLyndsey Jane Bannon, Daniel Fernando Andrade Ribeiro Dourado, David Andrew Lipscomb, Peter Brian Alexander McIntyre, Stefan Mix, Thomas Shaw Shaw Moody, Derek Quinn, Paul Daniel Jones, Anubhav P.S. Narula
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Abstract
Variants of Squalene Hopene Cyclase (SHC) isolated from Gluconobacter morbifer are provided as is a method for using the variant G. morbifer SHC to biocatalytically convert homofarnesol to ambrox.
Claims13
A recombinant vector comprising a nucleic acid molecule encoding a Squalene Hopene Cyclase (SHC) polypeptide having at least 90% sequence identity to SEQ ID NO:2 and including an amino acid alteration, relative to SEQ ID NO:2, at position 166, 222, 223, 226, 227, 242, 249, 504, 574, 640, 641, 676, 677, 682 or a combination thereof.
A recombinant Squalene Hopene Cyclase (SHC) polypeptide having at least 90% sequence identity to SEQ ID NO:2 and including an amino acid alteration, relative to SEQ ID NO:2, at position 166, 222, 223, 226, 227, 242, 249, 504, 574, 640, 641, 676, 677, 682 or a combination thereof.
Dependencies are inferred from the claim text.