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US 2023/0265391 A1Published application
Methods and compositions for making and using endocardial cells
AssigneeUniversity Health Network
InventorsGordon M. Keller, Alexander Mikryukov, Amine Mazine, Ian Fernandes
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Abstract
Methods and compositions for making endocardial cells from pluripotent stem cells are described, as are methods and compositions for using such cells.
Claims30
A method of producing a population of endocardial cells, comprising:
- providing cardiovascular progenitor cells;
- and
- contacting the cardiovascular progenitor cells with FGF and BMP under appropriate culture conditions,
- thereby producing a population of endocardial cells, wherein the population of endocardial cells is phenotypically NKX2-5+ and CD31+.
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Dependencies are inferred from the claim text.