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US 2023/0265388 A1Published application
Methods, kits, and compositions for enhancing cellular therapy
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsMaryam Rahman, Duane Mitchell, Rolando Lovaton, Hassan Azari
Life of this patent
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Abstract
Cell-based compositions and methods for targeting and treating human diseases, including cancers and infectious diseases, are provided, wherein exogenous intracellular sarcosine is used for improved delivery of the composition.
Claims22
A composition comprising an antigen presenting cell (APC),
- wherein the cell comprises a receptor for presenting antigen and antigen bound to the receptor, and wherein the cell contains at least 0.1 pg of sarcosine.
2-20. (Canceled)
A method for preparing a cell-based pharmaceutical preparation comprising:
- providing an antigen presenting cell comprising a receptor for presenting antigen and contacting the cell with a solution containing sarcosine.
A method of treating a disease in a subject, comprising:
- administering to the subject an antigen presenting cell (APC), wherein the cell comprises a receptor for presenting antigen and antigen bound to the receptor and wherein the cell contains at least 0.1 pg of sarcosine.
(canceled)
Dependencies are inferred from the claim text.