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US 2023/0265208 A1Published application
Antibodies against the muc1-c/extracellular domain (muc1-c/ecd)
AssigneeXyone Therapeutics Inc.
InventorsSurender KHARBANDA, Donald W. KUFE
Life of this patent
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Abstract
The present disclosure is directed to antibodies binding to MUC1-C/extracellular domain (MUC1-C/ECD) and methods of using such antibodies to treat cancers that express the MUC1 antigen.
Claims65
An antibody or fragment thereof that binds selectively to MUC1-C extracellular domain (MUC1-C/ECD) defined by SEQ ID NO:1, wherein said antibody comprises a variable heavy chain comprising CDR1, CDR2 and CDR3 regions of SEQ ID NOS:
- 3, 4, and 5, or 6, 7 and 8, and a variable light chain comprising CDR1, CDR2 and CDR3 regions comprising SEQ ID NOS:
- 9, 10 and 11, or 12, 13 and 14, respectively.
A fusion protein comprising:
- (i) a first single chain antibody that binds selectively to MUC1-C/extracellular domain (ECD) defined by SEQ ID NO:1, wherein said antibody comprises a variable heavy chain comprising CDR1, CDR2 and CDR3 regions of SEQ ID NOS:
- 3, 4, and 5, or 6, 7 and 8, and a variable light chain comprising CDR1, CDR2 and CDR3 regions comprising SEQ ID NOS:
- 9, 10 and 11, or 12, 13 and 14, respectively;
- and
- (ii) a second single chain antibody that binds to a T or B cell.
2 more elements
A chimeric antigen receptor comprising:
- (i) an ectodomain comprising single chain antibody variable region that binds selectively to MUC1-C/extracellular domain (MUC1-C/ECD) defined by SEQ ID NO:1, wherein said antibody comprises a variable heavy chain comprising CDR1, CDR2 and CDR3 regions of SEQ ID NOS:
- 3, 4, and 5, or 6, 7 and 8, and a variable light chain comprising CDR1, CDR2 and CDR3 regions comprising SEQ ID NOS:
- 9, 10 and 11, or 12, 13 and 14, respectively, with a flexible hinge attached at the C-terminus of said single chain antibody variable region;
- (ii) a transmembrane domain;
- and
- (iii) an endodomain,
- wherein said endodomain comprises a signal transduction function when said single-chain antibody variable region is engaged with MUC1.
4 more elements
Dependencies are inferred from the claim text.