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US 2023/0265201 A1Published application
Antibodies to cd70
Assigneeargenx BV
InventorsKaren SILENCE, Peter ULRICHTS, Johannes Joseph Wilhelmus DE HAARD, Torsten DREIER, Michael John Scott SAUNDERS, Harald WAJANT, Sofie Maria Elvire GABRIELS, Mahan MOSHIR
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Abstract
The present invention relates to antibodies and antigen binding fragments thereof which bind to the human CD70 protein with high affinity and display potent inhibition of tumour cell growth.
Claims21
1-49. (canceled)
A host cell comprising:
- (a) a first polynucleotide encoding a heavy chain variable domain (VH) comprising
- (i) an HCDR3 region comprising the amino acid sequence set forth in SEQ ID NO:
- 50 (DAGYSNHVPIFDS);
- (ii) an HCDR2 region comprising the amino acid sequence set forth in SEQ ID NO:
- 27 (DINNEGGTTYYADSVKG);
- and
- (iii) an HCDR1 region comprising the amino acid sequence set forth in SEQ ID NO:
- 11 (VYYMN), and
- (b) a second polynucleotide encoding a light chain variable domain (VL) comprising
- (i) an LCDR3 region comprising the amino acid sequence set forth in SEQ ID NO:
- 160 (ALFISNPSVE),
- (ii) an LCDR2 region comprising the amino acid sequence set forth in SEQ ID NO:
- 119 (NTNTRHS), and
- (iii) an LCDR1 region comprising the amino acid sequence set forth in SEQ ID NO:
- 250 (GLKSGSVTSDNFPT).
12 more elements
A vector comprising:
- (a) a first polynucleotide encoding a heavy chain variable domain (VH) comprising
- (i) an HCDR3 region comprising the amino acid sequence set forth in SEQ ID NO:
- 50 (DAGYSNHVPIFDS);
- (ii) an HCDR2 region comprising the amino acid sequence set forth in SEQ ID NO:
- 27 (DINNEGGTTYYADSVKG);
- and
- (iii) an HCDR1 region comprising the amino acid sequence set forth in SEQ ID NO:
- 11 (VYYMN), and
- (b) a second polynucleotide encoding a light chain variable domain (VL) comprising
- (i) an LCDR3 region comprising the amino acid sequence set forth in SEQ ID NO:
- 160 (ALFISNPSVE),
- (ii) an LCDR2 region comprising the amino acid sequence set forth in SEQ ID NO:
- 119 (NTNTRHS), and
- (iii) an LCDR1 region comprising the amino acid sequence set forth in SEQ ID NO:
- 250 (GLKSGSVTSDNFPT).
12 more elements
Dependencies are inferred from the claim text.