Compositions and methods for treating and preventing inflammation
AssigneeRsem, Limited Partnership
InventorsPrzemyslaw Sapieha, Normand Beaulieu
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Abstract
The present invention provides novel compounds compositions and methods for (i) treating or preventing inflammation; and (ii) preventing or reducing hyperactivation of innate immune response, by inhibiting NRP1-dependent cell-signaling. Also provided are compounds, composition, and methods of specifically inhibiting SEMA3A-mediated cell signaling.
Claims69
A method of treating or preventing inflammation comprising inhibiting NRP1-dependent cell-signaling in a subject.
A method of preventing or reducing hyperactivation of innate immune response comprising inhibiting NRP1-dependent cell-signaling in a subject.
The method of 22, wherein said purification domain is a polyhistidine tag.
The method of 4, wherein said method comprises reducing NRP1 expression by administering a NRP1 antisense, shRNA or siRNA.
The method of 4, wherein said method comprises reducing SEMA3A expression by administering a SEMA3A antisense, shRNA or siRNA.
A NRP1 polypeptide trap comprising a NRP1 polypeptide or a functional fragment or variant thereof which binds to SEMA3A, VEGF165 and/or TGF-β.
A compound for preventing or treating inflammation, wherein said compound:
- (a) reduces NRP1 expression or activity;
- and/or
- (b) reduces NRP1 ligand expression or activity.
A compound for preventing or reducing hyperactivation of innate immune response, wherein said compound:
- (a) reduces NRP1 expression or activity;
- and/or
- (b) reduces NRP1 ligand expression or activity.
Dependencies are inferred from the claim text.