Neuropilin-1 variant antibodies and methods of use
AssigneeTwist Bioscience Corporation
InventorsAaron SATO, Linya WANG, Fumiko AXELROD
Life of this patent
Estimating the term…
Abstract
Provided herein are methods and compositions relating to neuropilin-1 (NRP1) libraries having nucleic acids encoding for immunoglobulins that bind to NRP1. Libraries described herein include variegated libraries comprising nucleic acids each encoding for a predetermined variant of at least one predetermined reference nucleic acid sequence. Further described herein are protein libraries generated when the nucleic acid libraries are translated. Further described herein are cell libraries expressing variegated nucleic acid libraries described herein.
Claims32
An antibody or antibody fragment comprising a variable domain, heavy chain region (VH) and a variable domain, light chain region (VL), wherein the VH comprises at least 90% sequence identity to any one of SEQ ID NOs:
- 1-299, and wherein the VL comprises at least 90% sequence identity to any one of SEQ ID NOs 300-484.
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An antibody or antibody fragment comprising a variable domain, heavy chain region (VH) comprising at least 90% sequence identity to any one of SEQ ID NOs:
- 1-299.
14-24. (canceled)
A method of treating a disease or disorder comprising administering an antibody or antibody fragment that binds NRP1 comprising a variable domain, heavy chain region (VH) and a variable domain, light chain region (VL), wherein the VH comprises at least 90% sequence identity to any one of SEQ ID NOs:
- 1-299, and wherein the VL comprises at least 90% sequence identity to any one of SEQ ID NOs 300-484.
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A method of treating a disease or disorder comprising administering an antibody or antibody fragment that binds NRP1 comprising a variable domain, heavy chain region (VH) comprising at least 90% sequence identity to any one of SEQ ID NOs:
- 1-299.
38-48. (canceled)
A nucleic acid composition comprising:
- a) a first nucleic acid encoding a variable domain, heavy chain region (VH) comprising at least 90% sequence identity to any one of SEQ ID NOs:
- 1-299;
- b) a second nucleic acid encoding a variable domain, light chain region (VL) comprising at least 90% sequence identity to any one of SEQ ID NOs 300-484;
- and
- c) an excipient.
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A nucleic acid composition comprising:
- a) a first nucleic acid encoding a variable domain, heavy chain region (VH) comprising an amino acid sequence at least about 90% identical to a sequence as set forth in any one of SEQ ID NOs:
- 1-299;
- and
- b) an excipient.
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Dependencies are inferred from the claim text.