Humanized anti-tau(ps422) antibodies and methods of use

A humanized antibody that specifically binds to human Tau(pS422), wherein the antibody comprises

• in the heavy chain variable domain the HVRs of SEQ ID NO:
• 08, 77 and 10, and
• in the light chain variable domain the HVRs of SEQ ID NO:
• 12, 14 and 79.

A humanized bispecific antibody, comprising:

• i) a first binding site comprising a heavy chain variable domain of SEQ ID NO:
• 76 and a light chain variable domain of SEQ ID NO:
• 78;
• and
• ii) a second binding site selected from:
• a) a heavy chain variable domain of SEQ ID NO:
• 82 and a light chain variable domain of SEQ ID NO:
• 85, or
• b) a heavy chain variable domain of SEQ ID NO:
• 83 and a light chain variable domain of SEQ ID NO:
• 85, or
• c) a heavy chain variable domain of SEQ ID NO:
• 84 and a light chain variable domain of SEQ ID NO:
• 85.