One-armed antigen-binding molecules and uses thereof

Abstract

The present disclosure provides an antigen-binding molecule that comprises an antigen-binding moiety which specifically binds to an antigen and an Fc polypeptide comprising a first and second Fc region variants, with the first Fc region variant being fused to the antigen-binding moiety but the second Fc region variant being not fused to the antigen-binding moiety or to any other antigen-binding moieties which bind to the antigen, the antigen-binding molecule having a substantially decreased Fc gamma receptor-binding activity and having a maintained or increased C1q-binding activity when compared to an antigen binding molecule comprising the parent Fc region. The antigen-binding molecule of this format can enhance the clearance of the virus of interest while reducing the risk of ADE.

Dependencies are inferred from the claim text.