Antibody specifically binding to lgals3bp, and use thereof
AssigneesThe Asan Foundation, University of Ulsan Foundation for Industry Cooperation
InventorsSu Hwan CHANG, Song-Cheol KIM, Yeon Sook CHOI, Hyo Ri KIM
Life of this patent
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Abstract
An antibody or antigen-binding fragment thereof specifically binding to galectin 3-binding protein (LGALS3BP), and a use thereof, is described. The antibody or antigen-binding fragment thereof may comprise heavy chain CDRs and light chain CDRs of specific sequences. The antibody specifically binding to LGALS3BP has been found to inhibit cancer growth and metastasis in an animal model with cancer and may be effective for alleviating or treating cancer.
Claims10
An antibody or antigen-binding fragment thereof specifically binding to galectin 3-binding protein, comprising:
- a heavy chain variable region, comprising:
- a heavy chain CDR1 having an amino acid sequence represented by SEQ ID NO:
- 1,
- a heavy chain CDR2 having an amino acid sequence represented by SEQ ID NO:
- 2, and
- a heavy chain CDR3 having an amino acid sequence represented by SEQ ID NO:
- 3;
- and
- a light chain variable region, comprising:
- a light chain CDR1 having an amino acid sequence represented by SEQ ID NO:
- 4,
- a light chain CDR2 having an amino acid sequence represented by SEQ ID NO:
- 5, and
- a light chain CDR3 having an amino acid sequence represented by SEQ ID NO:
- 6.
An antibody or antigen-binding fragment thereof specifically binding to galectin 3-binding protein, comprising:
- a heavy chain variable region, comprising:
- a heavy chain CDR1 having an amino acid sequence represented by SEQ ID NO:
- 9,
- a heavy chain CDR2 having an amino acid sequence represented by SEQ ID NO:
- 10, and
- a heavy chain CDR3 having an amino acid sequence represented by SEQ ID NO:
- 11;
- and
- a light chain variable region, comprising:
- a light chain CDR1 having an amino acid sequence represented by SEQ ID NO:
- 12,
- a light chain CDR2 having an amino acid sequence represented by SEQ ID NO:
- 13, and
- a light chain CDR3 having an amino acid sequence represented by SEQ ID NO:
- 14.
7-15. (canceled)
Dependencies are inferred from the claim text.