US 2023/0265154 A1 · UNIVERSAL CHIMERIC ANTIGEN RECEPTOR T-CELL PREPARATION TECHNIQUE

Abstract

Provided are a universal chimeric antigen receptor (CAR) T cell and preparation method and application thereof. The binding of the cell HLA-A/HLA-B to the TCR is inhibited; the TCR gene expression is silenced; the invention man be used for allogeneic tumor treatment and does not cause GVHD and HVG reaction during allogeneic infusion, and thus improves the survival and antineoplastic effect of allogeneic CAR-T cells in the receptor.

Claims14

Dependent claims

A universal chimeric antigen receptor T cell (CAR-T cell) with the following characteristics:

(a) the CAR-T cell expresses a chimeric antigen receptor CAR, and the CAR targets a marker of tumor cells;
and
(b) the binding of HLA-A and/or HLA-B of the CAR-T cell to TCR (T cell receptor) is inhibited;
and the HLA-A and/or HLA-B gene expression of the CAR-T cell is silenced, so that the binding of HLA-A and/or HLA-B to TCR (T cell receptor) is inhibited.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

16/645,290Filed 6 Sep 2018

Priority

CN 201710797952.46 Sep 2017

Published

24 Aug 2023

Term ends

Not estimatedThe source records don’t support an estimate.

Classification26 codes

A61K 48/005
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy:…
C07K 14/7051
Immunoglobulin superfamily: t-cell receptor -CD3 complex
A61K 40/11
Characterised by the cell type used: t-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer…
A61K 40/22
Characterised by the effect or the function of the cells: immunosuppressive or immunotolerising

Universal chimeric antigen receptor t-cell preparation technique

Life of this patent

Universal chimeric antigen receptor t-cell preparation technique

Life of this patent

Abstract

Claims14