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US 2023/0265149 A1Published application
Encapsulated cells expressing il-2 and uses thereof
AssigneeWilliam Marsh Rice University
InventorsOmid VEISEH, David ZHANG, Sudip MUKHERJEE, Maria RUOCCO, Michael DOERFERT, Amanda NASH, Samira AGHLARA-FOTOVAT
Life of this patent
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Abstract
The present disclosure relates to implantable constructs (encapsulated cells) designed to deliver antigenic therapeutic reagents, such as IL-2.
Claims21
1-68. (canceled)
A population of encapsulated cells comprising an oligonucleotide molecule encoding native human IL-2.
A method of preparing encapsulated cells producing a recombinant protein, the method comprising:
- feeding through a coaxial needle a first composition comprising a polymeric hydrogel and a second composition comprising cells to be encapsulated suspended in a polymeric hydrogel to drop into a crosslinking solution to form the encapsulated cells, wherein the crosslinking solution comprises a sugar alcohol, a buffer, a metal salt, and a surfactant.
Dependencies are inferred from the claim text.