Loading patent…
AssigneesThe Trustees of the University of Pennsylvania, The Board of Trustees of the Leland Stanford Junior University
InventorsMikko SIURALA, Carl H. JUNE, Kenan Christopher GARCIA, Maria Sofia CASTELLI CORTÉS, Regina M. Young
Estimating the term…
The present disclosure provides chimeric cytokine receptors comprising an intracellular signaling domain of an interleukin-9 receptor alpha (IL9Ra). The present disclosure also provides modified cell(s), i.e., immune cell(s) or precursor cell(s) thereof, wherein the cell(s) are engineered to express a) interleukin-9 receptor alpha (IL9Ra), or a chimeric cytokine receptor disclosed herein; and b) a chimeric antigen receptor (CAR). The present disclosure further provides a vector (e.g., an oncolytic adenoviral vector) comprising a nucleic acid sequence encoding a cytokine, as well as methods of using the modified cells and the vector for treating cancer in a subject in need thereof. Also provided are modified immune cell(s) or precursor cell(s) thereof which are engineered to express a chimeric antigen receptor (CAR), wherein expression of Cullin 5 in the cell(s) is reduced and/or eliminated. Also provided are methods and uses of the modified cells, e.g., for treating at least one sign and/or symptom of cancer. Related nucleic acids, vectors, and pharmaceutical compositions are also provided.
A chimeric cytokine receptor, comprising:
An isolated nucleic acid comprising:
15-16. (canceled)
27-37. (canceled)
(canceled)
A system for enabling IL9 signaling in a cell, the system comprising:
43-60. (canceled)
62-79. (canceled)
82-110. (canceled)
A chimeric cytokine receptor comprising an extracellular domain comprising a ligand-binding domain (LBD) of an inhibitory immunoreceptor or an anti-checkpoint inhibitor antigen binding domain, a transmembrane domain, and an intracellular domain comprising an intracellular signaling domain of an interleukin-9 receptor alpha (IL9Ra).
(canceled)
(canceled)
An isolated nucleic acid comprising:
121-135. (canceled)
(canceled)
139-153. (canceled)
156-172. (canceled)
Dependencies are inferred from the claim text.