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AssigneeAz. Bd. of Reg. on Behalf of the Univ. of Arizona
InventorsRobin L. Polt, Lajos Z. Szabo, John M. Streicher, Parthasaradhireddy Tanguturi
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The present invention provides cyclic oligopeptides and methods for using the same. The cyclic oligopeptides of the invention are analogues of oxytocin wherein the disulfide linkage between Cys1 and Cys2 are replaced with a more stable amide bond. The cyclic oligopeptides of the invention can also include a glycoside to increase blood-brain barrier penetration. In particular, the cyclic oligopeptide of the invention is of the formula: (A) (SEQ ID NO:2) where one of AA1 or AA6 is an amino acid having a carboxylic acid side-chain and the other is a carboxylic acid having an amine functional group on the side-chain such that X1 and X2 together form an amide bond; and each of AA2-AA5 and AA7-AA11 is independently natural or unnatural amino acids with at least one, typically at least two, often at least three, more often at least four, and most often at least five of which is an amino acid that is present in the corresponding position of oxytocin.
A cyclic oligopeptide of the formula:
A method for treating a clinical condition to a subject in need of such a treatment, said method comprising administering to said subject a therapeutically effective amount of a cyclic oligopeptide of the formula:
Dependencies are inferred from the claim text.