Back to results
US 2023/0265108 A1Published application
Gold(iii) compounds and cancer cell-selective modulation of mitochondrial respiration and metabolism
AssigneeUniversity of Kentucky Research Foundation
InventorsSamuel Awuah, Randall Tyler Mertens
Life of this patent
Estimating the term…
Abstract
A compound of formula (I) is provided. Useful compounds and compositions, and methods of making and methods of using such compounds and compositions. The subject matter also relates to methods of treating cancer using compounds and compositions provided.
Claims21
1-45. (canceled)
A compound having the formula (I) or a pharmaceutically acceptable salt thereof:
- wherein,
- X is selected from the group consisting of CH, C═O, C═NO-alkynyl, NH, O, S, or aryl;
- R is selected from the group consisting of H, aryl, alkyl, electron withdrawing group (EWG), or electron donating group (EDG);
- R1 and R2 are independently selected the group consisting of alkyl and substituted alkyl, or, R1 and R2, taken together with the N to which they are bound, form a piperidine or piperazine that is optionally substituted with Z;
- and
- Z is selected from the group consisting of haloaryl and alkoxyaryl.
3 more elements
Dependencies are inferred from the claim text.