Back to results
US 2023/0265104 A1Published application
Novel heterocyclic compounds
AssigneePRISM BioLab Co., Ltd.
InventorsHajime TAKASHIMA, Eiji HONDA, Tomonori TAGURI, Jun OZAWA, Haruyuki NISHIDA, Yoichiro HIROSE, Keisuke KIMURA
Life of this patent
Estimating the term…
Abstract
A compound of the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a pharmaceutically acceptable salt thereof has a superior inhibitory activity on cancer cell proliferation.
Claims22
A compound represented by the following formula (I):
- wherein
- Q is a hydrogen atom or is represented by any of the following formulas (II-1) to (II-8):
- R1 is a hydrogen atom, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl, optionally substituted heteroarylalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocycloalkylalkyl, or —(CO)—R1a;
- R1a is optionally substituted alkyl, optionally substituted alkoxy, optionally substituted aryl, or optionally substituted heteroaryl;
- R1b is a hydrogen atom, or 1 to 3 same or different alkyls;
- Q1a is a single bond, optionally substituted alkylene;
- Q1b is a hydrogen atom, hydroxy, halogen, cyano,-Q1c, —COQ1c, —CONQ1cQ1d, CONQ1c—OQ1d, —NQ1cQ1d, or —OQ1c;
- Q1c is a hydrogen atom, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl;
- Q1d is a hydrogen atom or optionally substituted alkyl;
- Q2a is optionally substituted cycloalkylene;
- Q2b and Q2c are the same or different and each is a hydrogen atom or optionally substituted alkyl;
- U is —CO— or —CH2—;
- R2 is a hydrogen atom, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted arylalkyl, optionally substituted heteroarylalkyl, optionally substituted cycloalkylalkyl, or —X—N(R2a)(R2b);
- X is an alkylene group;
- R2a and R2b are the same or different and each is a hydrogen atom, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl, optionally substituted heteroarylalkyl, or optionally substituted cycloalkylalkyl;
- V is an optionally substituted aryl ring, an optionally substituted heteroaryl ring, an optionally substituted partially saturated heteroaryl ring, or an optionally substituted heterocycloalkyl ring;
- R3 is a hydrogen atom, hydroxy, halogen, cyano, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, —C≡C—R3a or —COOR3b;
- R3a is a hydrogen atom, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, or optionally substituted heteroaryl,
- R3b is a hydrogen atom or optionally substituted alkyl,
- is represented by any of the following formulas (III-1) to (III-4):
- R4 is a hydrogen atom, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted arylalkyl, optionally substituted heteroarylalkyl, optionally substituted cycloalkylalkyl, or optionally substituted heterocycloalkylalkyl, and
- Ar2 is an optionally substituted aryl ring or an optionally substituted heteroaryl ring;
- and
- R5 is a hydrogen atom, or optionally substituted alkyl;
- and
- R6 and R7 are the same or different and each is a hydrogen atom or halogen,
- or a pharmaceutically acceptable salt thereof.
24 more elements
(canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.