Endoscopic system and methods having real-time medical imaging

A system for enhancing abnormality detected by an endoscopist during an endoscopic procedure, the system comprising:

• an endoscopy system having an endoscope, the endoscopy system configured to output a video stream of an interior surface of an organ;
• a monitor having first and second windows;
• an electronic memory having instructions stored therein, the instructions including a 3D reconstruction module, a conformal mapping module and a display module;
• and
• a processor operationally coupled to the endoscopy system and the monitor, the processor configured to access the electronic memory and execute the instructions stored therein such that:
• the 3D reconstruction module analyzes the video stream to generate in, at least near real time, a 3D model of the interior surface by concatenating slices created from the video stream;
• the conformal mapping module analyzes the video stream to generate a 2D flat image of the interior surface, and
• the display module renders an image of the 3D model for viewing in the first window and the displays the 2D flat image in the second window,
• wherein at least one of the image or 2D flat image facilitates navigation of the endoscope by the endoscopist within the organ.