Compositions and Methods for Treating Hemorrhagic Shock

A method for preventing or treating hemorrhagic shock, the method comprising intravenously administering to a subject in need thereof an effective amount of an oxygenation complement comprising a hemoglobin-based oxygen carrier (HBOC) and blood plasma, in an effective amount to prevent or treat hemorrhagic shock in the subject.

A liquid low ionic solute HBOC preparation comprising no more than about than about 27 milliequivalent (mEq/L) sodium ions (Na+), no more than about 0.7 mEq/L potassium ions (K+) ions, no more than about 0.92 mEq/L calcium ions (Ca2+), no more than about 0.3 mEq/L magnesium ions (Mg2+) ions, no more than about 19.2 mEq/L chloride ions (Cl−) ions, no more than 4.8 mEq/L bicarbonate ions (HCO32−), and no more than about 0.5 mEq/L hydrogen phosphate ions (HPO42−).