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US 2023/0234850 A1Published application
Adjuvanted vaccines
AssigneeMerck Sharp & Dohme Corp.
InventorsAkhilesh Bhambhani, Muneeswara Babu Medi, Maya Salnikova, William James Smith, David S. Thiriot
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Abstract
Vaccine formulations are described comprising physically separated, lyophilized antigens and adjuvant components, which may be in lyoparticle form, as well as methods of using and making such formulations. Reconstituted formulations are also described.
Claims9
1-18. (canceled)
An article of manufacture comprising components
- (1) an antigen, which is dried (i) or in solution (ii);
- (2) a dried aluminum-containing and/or calcium-containing reagent;
- and
- (3) a dried phosphate reagent and, optionally, a base;
- wherein each of components (1), (2) and (3) are physically separated from the other components and co-packaged;
- and
- wherein said aluminum-containing and/or calcium-containing reagent and said phosphate reagent and, optionally, the base, react when reconstituted with water to form an adjuvant.
4 more elements
22-36. (canceled)
Dependencies are inferred from the claim text.