Pharmaceutical combination comprising a brain aminopeptidase a inhibitor, a diuretic and a blocker of the systemic renin-angiotensin system
AssigneesQuantum Genomics, Institut National de la Sante et de la Recherche Medicale, Centre National De La Recherche Scientifique, College De France
InventorsFABRICE BALAVOINE, CATHERINE LLORENS-CORTES, YANNICK MARC
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Abstract
The present invention relates to a pharmaceutical combination comprising (i) firibastat, (ii) a diuretic and (iii) a blocker of the systemic renin-angiotensin system selected from the group consisting of angiotensin I converting enzyme inhibitors (ACEIs) and angiotensin II receptor type 1 (AT1R) antagonists. Said composition is particularly useful for the treatment of hypertension and related diseases and conditions.
Claims21
1-21. (canceled)
A method of treating arterial hypertension or indirectly or heart failure comprising administering a pharmaceutical combination comprising (i) firibastat, (ii) a diuretic and (iii) a blocker of the systemic renin-angiotensin system selected from the group consisting of angiotensin I converting enzyme inhibitors and angiotensin II receptor type 1 antagonists to a subject in need of treatment.
A kit of parts comprising a pharmaceutical combination containing (i) firibastat, (ii) a diuretic, (iii) a blocker of the systemic renin-angiotensin system selected from the group consisting of angiotensin I converting enzyme inhibitors and angiotensin II receptor type 1 antagonists, in the form of one, two or three separate units of the components (i) to (iii), for a simultaneous or sequential administration.
Dependencies are inferred from the claim text.