Chimeric antigen receptor, macrophage expressing same, method for adjusting macrophage polarization, and use thereof
AssigneeZhejiang University
InventorsJin ZHANG, Lin TIAN, Anhua LEI
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Abstract
Provided are a chimeric antigen receptor, a macrophage expressing same, a method for adjusting macrophage polarization, and the use thereof. The intracellular domain of the chimeric antigen receptor contains an IFN-γ receptor, and the macrophage expressing the chimeric antigen receptor can maintain an M1 type status for a relatively long time, thereby enhancing the activity of the macrophage M1 type after tumor cell antigens are combined with the chimeric antigen receptor.
Claims7
A chimeric antigen receptor, wherein the chimeric antigen receptor contains an IFN-γ receptor, and the IFN-γ receptor is located in an intracellular domain of the chimeric antigen receptor.
Dependencies are inferred from the claim text.